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Although she no longer takes the drug, Wilson told the newspaper that the GLP-1 medication helped her address harmful behaviors like binge eating

Foods to avoid in the FODMaP diet have shown to trigger an osmotic fluid shift into the lumen of the intestine, which worsens symptoms in those with diarrhea-predominant IBS.[53] This may explain the findings in one study where the FODMaP improved symptoms by 50% for both diarrhea and constipation-predominant IBS, but only reduced stool frequency for IBS that was diarrhea-predominant.[54] Now that we have a better understanding of the pathophysiology of how certain sugars can worsen GI symptoms, we can treat the symptoms by modifying the diet

Cell Rep (2018) 23(1):23954.e6

Notably, AMPK activation by metformin or sustained TGF- signaling enhances Treg generation and facilitates Th17-to-Treg conversion, highlighting its role in immune tolerance (82, 83)