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(2016) found the most common comorbities in MCAS, occurring in over 10% of patients, were gastroesophageal reflux disease (GERD) 35% hypertension 29% multiple/atypical drug reactions 23% abdominal pain not otherwise specified 22% hysterectomy/oophorectomy 21% hyperlipidemia 20% cholecystectomy 20% environmental allergies 19% tobacco abuse 18% asthma 18% diabetes mellitus type 2 17% hypothyroidism 17% headaches 17% depression 16% sinusitis 16% fibromyalgia 16% anemia of chronic inflammation 15% sleep apnea 15% frequent upper respiratory tract infections 15% miscarriage 15% pharyngitis (sore throat caused by inflammation) or tonsillitis 14% dysmenorrhea 14% thromboembolism 13% frequent or atypical infections 13% obesity 13% osteoarthritis 13% anxiety/panic 12% vertebral disease 12% cardiovascular malformations 12% dermatitis 11 % presyncope or syncope 11 % interstitial cystitis 11 % chronic kidney disease 10% POTS 10% [4] MCAS is often diagnosed in patients that have been previously diagnosed with Ehlers-Danlos syndrome (EDS), a heritable connective tissue disorder, and with postural orthostatic tachycardia syndrome (POTS), a form of orthostatic intolerance

Phosphodiesterase 10A inhibition improves cortico-basal ganglia function in Huntingtons disease models