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It shields neurones from oxidative damage and nitrosative stress, primarily by lowering lipid and protein oxidation, increasing enzymatic and non-enzymatic antioxidant markers, and reviving mitochondrial activity ( in vitro and in vivo , and reduced A-induced cognitive impairment by lowering lipid peroxidation and restoring glutathione in the hippocampus in Alzheimers disease models ( ex vivo systems, and inhibited microglial activation in lipopolysaccharide (LPS)induced Parkinsons disease (PD) models ( 3.3.7 Interaction with mitochondrial and hepatic receptors Silymarins therapeutic efficacy is regulated by its interactions with mitochondrial and hepatic receptor systems, which together control its bioactivation and intracellular signalling responses

Gracey M, Burke V, Anderson CM

Results: The analysis yielded three primary categories: communication barriers, insufficient structural resources, and lack of person-centred care

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