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GRP78, a central sensor of the UPR, binds unfolded proteins via its N-terminal domain and interacts with UPR signaling branches through its C-terminal domain, maintaining these pathways in an inactive state under basal conditions (Wu et al., 2015)

These are natural substances, such as blood components, cells, and growth factors, that can speed up the healing process of damaged tendons, ligaments, muscles, and bones