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Warn patients of the potential danger of self-administration of benzodiazepines, other CNS depressants, opioid analgesics, and alcohol while under treatment with SUBLOCADE

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In the present study, there was a significant increase in the post-operative level of the oxidative stress marker MDA but a significant decrease in the SOD antioxidant enzyme in patients of both groups compared to their baseline values, which is in agreement with other studies that reported an increase in oxidative stress after pediatric open-heart surgery [26, 27]