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Resistance to tetracycline would fall under an intrinsic classification and would include outer membrane permeability, expression efflux pumps or production of antibiotic-inactivating enzyme, whereas the development of resistance to cefepime and ciprofloxacin would fall under adaptive resistance ( pmtA mutant has a weakened ability to form biofilms, this phenomenon could explain the increased sensitivity to these two therapeutics

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Specialized evaluation systems (SESs) remain underdeveloped for specific wound types (SWTs) including burn wounds and diabetic foot ulcers (DFUs), complicating therapeutic efficacy comparison and analysis

Hsieh et al., 2020