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demonstrated promising antitumor effects, its translational potential warrants more rigorous scrutiny, particularly regarding whether the applied neutron dose falls within a clinically safe therapeutic window, whether the tumor-to-normal tissue 10 B accumulation ratio is sufficient for selective cytotoxicity, and whether appropriate control groups were included to rule out nonspecific effects

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In M1-type microglia, increased pentose phosphate pathway activity and aerobic glycolysis are associated with excessive production of ROS