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Especially, the detailed knowledge of the nanocarrier-transporter complex internalization and following sorting processes and exocytosis would enable rational design of nanocarriers capable of efficient transcytosis across the BBB by minimizing the lysosomal degradation of the nanocarrier in the endothelial cells

Second, 2-10fold charged precursors were selected by the build in quadrupole (isolation window 1.6)

TABLE 2 A summary of different types of nanoparticles, the loaded cargo, particle size, and advantages of drug encapsulation in melsma management

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