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In rodent studies, orally administered curcumin was primarily detected in the stomach and small intestine, accounting for approximately 90% of the curcumin, with only trace amounts of unchanged curcumin in the liver and kidney ( Similarly, in a separate study, mice injected intraperitoneally with radioactive carbon ( 14 C) curcumin showed peak radioactivity levels in various tissues, with the liver and intestinal mucosa having the highest peaks

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