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This appears to be the case for retinoic acid receptor responder protein-1 (RARRES1), a podocyte-enriched transmembrane protein whose expression is increased in kidney biopsies of patients with glomerular diseases ( in vivo , which associated with worsen tubular injury, as assessed by tubular vacuolation and kidney injury molecule-1 expression ( in vitro and in vivo ( Cytotoxicity of complement components and complement activation Under proteinuric conditions, aberrantly filtered complement precursors enter the tubular lumen, where they can be activated on tubular membranes

FRDA, a disorder affecting many inaccessible cell types, represents a model disease for which the use of iPSCs may provide exciting breakthroughs in mechanistic studies and drug discovery programs (see Graphical Abstract)

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Choice E: "Why haven't you been able to stay off cigarettes?" is a "why" question that focuses on past failures