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Recent evidence suggests the existence of a third COX isoform, designated COX-3 , with roles in mediating pain and fever, and subject to inhibition by acetaminophen

doi: 10.1074/jbc.M116.731703 161 MlzerCWallnerMKernCTosevskaASchwarzUZadnikarRet al

Nat Cell Biol 2000, 2: 423427

We improved on the new reconstruction by mapping the genes and reactions of the GEM to Recon3D, a standard human metabolic model, MetaNetX 4.2, BiGG, ChEBI, MetaCyc, and PubChem databases (Caspi et al, 2014