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Methyltransferase-like 3 (METTL3) can directly target the m6 modification of SLC7A11, which enables m6A reading protein YTHDF1 to recognize the mRNA of SLC7A11, and then promote the expression of SLC7A11 by enhancing its stability and translation, thereby inhibiting ferroptosis [81]

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The malignant cells often nest or cluster in groups in an organoid fashion

PubMed Sikiric, P., Hahm, K.B., Blagaic, A.B., Tvrdeic, A., Pavlov, K.H., Petrovic, A., Kokot, A., Gojkovic, S., Krezic, I., Drmic, D., Rucman, R., & Seiwerth, S