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References 1 ChevionMBerenshteinEStadtmanER

It reduces levels of pro-inflammatory cytokines (including TNF-alpha) and dampens oxidative stress, the two drivers most linked to the visible signs of skin aging

In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)

Even though heavy metals are abundant in nature at particular places, their exposure to humans was limited due to the abundance of these metals in various nonhabitat areas in the past