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This compound specifically inhibits the activation of the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway induced by radiation, significantly downregulates the secretion of pro-inflammatory cytokines TNF- and IL-6 following radiation exposure, and is closely associated with its regulation of NF-B nuclear translocation and inhibition of NLRP3 inflammasome activation (Zheng et al., 2013)

Roy J, Galano JM, Durand T, Le Guennec JY, Chung-Yung LJ