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Acknowledgments This work was supported by NIH grant DK45334 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

Primarily characterized by progressive degradation of articular cartilage, subchondral bone sclerosis, synovial inflammation, and weakened periarticular muscle strength (1), OA poses a substantial socioeconomic burden, with direct and indirect healthcare costs estimated at approximately 12.5% of the gross domestic product (GDP) in developed countries (2)

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