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The connected gene-gene networks included the terms: adaptive immunity, interferon, M2 macrophages, ECM, and proliferation. A meta-analysis of genes expressed in multiple end-target organs including the skin, the lung, the esophagus and the peripheral blood provided evidence for the occurrence across organs of the intrinsic subsets, pointing to the existence of pro-fibrotic macrophages in multiple tissues [174]

Thymosin beta4 prevents oxidative stress, inflammation, and fibrosis in ethanol- and LPS-induced liver injury in mice

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