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In very rare cases, serious hypersensitivity reactions can occur after B12 injections, requiring immediate medical attention

Some enzymes genetically break it down better than others (one of the reasons some handle alcohol than others.) This alcohol breakdown in the liver creates molecules that can lead to the production of reactive oxygen species (ROS) free radicals - tiny, very active molecules that contain oxygen

As many as 24% of men and 29% of women reported taking a supplement (either a multivitamin that contains B12, a B-complex vitamin, or a standalone B12 supplement), according to the National Health and Nutrition Examination Survey (NHANES)