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Those who suffer from Imerslund-Grasbeck disease , a genetic disorder, are unable to absorb dietary B12

This lethal outcome may be result of an accumulation of endogenous formaldehyde in mouse fetuses or neonates by inactivating both ADH5 and ALDH2

This ability to generate H2O2, which is capable of diffusing across membranes and acting as a signaling molecule, implies a role for NOX4 in cellular signaling and regulation (100)