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37 Although co-use of other drugs, such as stimulants, with medications for OUD can interfere with treatment, it remains safer for patients to continue medication treatment because of their high risk for overdose from using illicit opioids

Just as astrocyte and microglial modulation must be targeted with precision, clinical trials must recruit the right patients through robust diagnostic enrichment

Evidence of benefit is lacking for long-term weight loss with some data supporting weight gain and heart disease risks.It is stable under heat and over a broad range of pH conditions