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Moreover, we showed that mAb M51 binds the MetE immunoprecipitated from Mtb culture supernatant by mAb M29 ( Figure 1C ), confirming (i) the good quality and the right conformation of the native recombinant protein that we produced and (ii) that these two high-specific mAbs recognize different, non-overlapping epitopes in the more Mtb-specific sequence of MetE

This reprogramming is driven by alterations in glycolytic enzymes regulated by the UPS

As the biologically active fragment Ac-SDKP, it is primarily studied for its roles in actin upregulation and cellular mobility, angiogenesis and new blood vessel formation, collagen architecture and extracellular matrix remodeling, reduction of fibrotic scarring in soft tissue models, and systemic recovery signaling across multiple tissue types

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