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Proteins involved in antioxidant defense system Mass spectrometry data showed that various antioxidant enzymes such as GSTT2, GSTM1 and GSTA1/2/5 that helps to eliminate toxic metabolites generated by oxidative stress were upregulated in response to ibuprofen treatment in male mice livers than controls

Long-term use at physiological or modestly supraphysiological doses hasn't raised safety concerns in the existing literature

Subsequent examination of biochemical markers such as MMA or homocysteine may show that these markers are moderate to highly elevated

Expert team physicians identified bruising during the systematic injection site inspection