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Cocaine binding to sigma receptors evokes a proteolytic signal cascade that initiates PDGF-B chain assembly, a fundamental intermediate for increased membrane permeability that inhibits store-operated calcium entry (Yao et al., 2011

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Notably, glutathione amino acid precursors protective capabilities against menadione-induced oxidation were found to surpass those of ascorbic acid (AA), suggesting a superior antioxidant mechanism