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Abbreviations BMI: Body Mass Index DNA: Deoxyribonucleic Acid DUSP1: Dual Specificity Phosphatase 1 ESAM: Edematous Severe Acute Malnutrition F/B: Firmicutes to Bacteroidetes ratio FTO: Fat Mass and Obesity-Associated Gene GH: Growth Hormone GPCR: G-Protein Coupled Receptors GPx3: Glutathione Peroxidase 3 GRP78: Glucose-Regulated Protein 78 H3Ac: Histone H3 Acetylation H3K20me3: Histone H3 Lysine 20 Trimethylation H3K4me3: Histone H3 Lysine 4 Trimethylation H3K9me: Histone H3 Lysine 9 Mono- or Di-Methylation H3K9me3: Histone H3 Lysine 9 Trimethylation H4Ac: Histone H4 Acetylation HDAC: Histone Deacetylase IDH1: Isocitrate Dehydrogenase 1 IGF-1: Insulin-like Growth Factor 1 IL-10: Interleukin 10 IL-18: Interleukin 18 IL-6: Interleukin 6 KAZN: Kazrin gene KMT1A: Lysine Methyltransferase 1 A (also known as SUV39H1) LPIN1: Lipin 1 LXR: Liver X Receptor Alpha MUAC: Mid-Upper Arm Circumference MAFLD: Metabolic DysfunctionAssociated Fatty Liver Disease NESAM: Non-Edematous Severe Acute Malnutrition NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells PDE3A: Phosphodiesterase 3 A PDGFR: Platelet-Derived Growth Factor Receptor PMN: Peripheral Mononuclear Cells PPARG: Peroxisome Proliferator-Activated Receptor Gamma RNA: Ribonucleic Acid SAM: Severe Acute Malnutrition SCFA: Short Chain Fatty Acids SIRT1: Sirtuin 1 Gene SLC17A9: Solute Carrier Family 17 Member 9 T3: Triiodothyronine T4: Thyroxine TDH: L-Threonine Dehydrogenase TGF-: Transforming Growth Factor Beta TNF: Tumor Necrosis Factor TSH: Thyroid-Stimulating Hormone WHZ: Weight-for-Height Z-score mTOR: Mechanistic Target of Rapamycin References World Health Organization

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d Activity is also present in the cytosol