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used the highest prophylactic MT dose (80 mg/kg) that did not produce any signs of toxicity in mice in their 2021 study (Labban et al

Emodin decreases GSH content, xCT and GPX4 expression, increases ROS generation, MDA, and lipid peroxidation, effects reversed by ferroptosis inhibitors and autophagy inhibitors, iron chelator DFO, ferostatin-1, and NCOA4 silencing