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Immunology 7 , e592 (2016)

However, as age increases, the balance between ROS production and antioxidant defenses deteriorates, leading to chronic oxidative stress across organ systems

doi: 10.3389/fphys.2018.00095 Received 25 October 2017 Accepted 29 January 2018 Published 14 February 2018 Volume 9 - 2018 Edited by Ali Mobasheri, University of Surrey, United Kingdom Reviewed by Felipe Simon, Universidad Andrs Bello, Chile