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NACC, whose mechanism of action remains unclear, demonstrated selective anticancer activity, and low toxicity, which make NACC and its analogs promising anticancer agents ( Another approach was to use the sulphonamidase activity of GST

Hurley JH, Young LN (2017) Mechanisms of autophagy initiation

The specific mechanism by which enzymatic reactions cause lipid peroxidation is that Acyl-CoA synthetase long-chain family member 4 (ACSL4) and Lysophosphatidylcholine acyltransferase-3 (LPCAT3) first activate polyunsaturated fatty acids (PUFAs) to bind to lipids in the cell membrane (e.g., phosphatidylethanolamine PE), forming the PUFA-PE complex (Su et al., 2019)

Procarbazine, lomustine and vincristine for recurrent high-grade glioma