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During the lysis of autophagosomes, ROC-325 can inhibit the formation of autophagolysosomes by increasing lysosomal membrane permeability and lysosomal deacidification, and it can significantly reduce the autophagic flux in PAECs and activate the nitric oxide signaling pathway, which in turn improves right ventricular dysfunction and pulmonary vascular remodeling in hypoxic PH rats [100]

Osteogenic markers, including BMP-2, Osterix, Collagen type I and Osteocalcin, are upregulated to induce osteogenesis (82,83)

We merged genes from the three databases to create a gene set for each pathway (Additional file 1: Tables S2S4), resulting in 5325, 2557, and 3435 genes for Most Studied Pathways, Gene-Associated Pathways, and Popular Pathways, respectively

Wang D, Li D, Zhang G, Wang C, Wei G (2019a) Disruption of por1 gene in Candida utilis improves co-production of S-adenosylmethionine and glutathione