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Treatment with 5-HD preserves membrane permeability and integrity, which also drastically reduces animal mortality [89]

Plasma ANG II level, the active form of Agt, was not significantly different, although a trend toward an increase in resistin-treated mice was observed (Fig

Cell (2021) 184:22642.e21

Similar mechanisms may be responsible for the enhanced vasodilatory action of peroxynitrite (ONOO) in the presence of GSH: peroxynitrite reacts with GSH to form S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged period of time, thus extending NO's half-life and, as a result, relaxing vascular tone (25)