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Metabolic tracer studies in humans demonstrate that adipose tissue derived FAs account for the majority of hepatic TAGs in FLD patients, suggesting that dysregulation of adipocyte lipolysis is a major mechanism of diet-induced FLD (203) (Figure 5)

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This efficacy differential highlights an important trade-off in the oral GLP-1 space: orforglipron offers the convenience of oral administration and freedom from injection but, based on current data, produces somewhat less weight loss than the most potent injectable multi-receptor agonists