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Why desensitization doesnt apply at low doses: AMPK isnt a receptor in the classical sense its an intracellular kinase

Folli F, Corradi D, Fanti P, Davalli A, Paez A, Giaccari A, Perego C, Muscogiuri G

Nevertheless, the fact that no temperature changes were observed across the human NREM-REM cycle does not rule out the possibility that peripheral temperature changes can induce alterations in sleep stages