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We show in this study that SapM is able to hydrolyse all seven phosphoinositides albeit with higher specificity for PI(4,5) P 2 and PI3 P , and to our knowledge, SapM is the first bacterial phosphatase to show such a broad PI activity

These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)