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77 Wang et al 78 found that CYP2E1-targeting RNAi delivered via lipid nanoparticles alleviated hepatic lipid accumulation, inflammation, and fibrosis in ALD mice, suggesting its therapeutic potential for ALD

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For instance, the conditional knockout of Gpx4 in kidney cells, T cells, or B cells can induce ferroptotic damage, which can be reversed by supplementing with vitamin E or the ferroptosis inhibitor liproxstatin-1 [58, 59, 122, 123]