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In: Adam MP, Ardinger HH, Pagon RA, et al (eds) GeneReviews [Internet]

Medicine 94(42): e1730

Finally, using transcription factor motif analysis, we observed that there is more than one binding site motif for ATF4 in the upstream promoter (approximately 1000 bp upstream of the transcription start site) regions of GPX4 , GSS , NFE2L2 , ATG3 , ATG4D , and other genes, and all the sites have the [TGACGTGGC(A/G)] basic motif sequence (Figure 5E)

However,translating success from a sterile laboratory mouse to a human living with complex, multi-factorial Crohn's disease or ulcerative colitis is incredibly difficult