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It has shown effectiveness in delaying tumor progression in recurrent brain tumor patients but has limited benefits on overall survival in real-world clinical setting [23]

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Additionally, FDA cited Zoll for failing to follow MDR reporting requirements, including incidents where there may have been a reasonable concern of a product malfunction, and the company didn't notify the agency within the required timeframe

Figure 1 The key to understanding PEM lies in elucidating why exercise, which is generally protective in healthy individuals, induces pathological exacerbation in patients with PEM ( Thus, our study aims to synthesize pathophysiological evidence of energy metabolism, immune inflammation, and neurovascular system abnormalities observed following physical or cognitive exertion