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To assess glucose tolerance, mice were fasted for 16 h overnight

Environ pollut

In ferroptosis, SLC7A11 and GSH depletion lead to iron-dependent ROS accumulation ( Ferroptosis and alzheimers disease Iron homeostasis and alzheimers disease Regulation of iron homeostasis is important for maintaining normal brain function, and dysregulation of iron homeostasis in the brain can lead to oxidative stress and inflammatory responses, resulting in cell damage and ultimately neurodegenerative diseases

Dose Titration We start patients at a conservative dose and titrate upward over the first 8 to 12 weeks based on response and tolerance