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[Abstract] H460 and H1299 cells were treated with erianin with or without the ROS scavenger GSH (1 mM) for 24 h, and cell viability was assayed

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The interaction between -catenin and FOXO transcription factors promotes cell quiescence and cell cycle arrest

A translational review on NNMT inhibitor clinical development ( Emerging opportunities for NNMT inhibitor clinical translation , ScienceDirect, 2026) points out that alternative routes like polyamine biosynthesis could compensate for the raised SAM, and that partial rather than total inhibition might even be preferable specifically to avoid triggering those compensatory mechanisms from a chronically imbalanced SAM/SAH ratio