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However, relapse, recurrency, and therapeutic resistance are serious challenges in the fight against this complex and debilitating disease [36]

ALF due to WD, accounting for approximately 3% of all ALF, is typically associated with nonimmune (Coombsnegative) intravascular hemolysis, coagulopathy, progressive encephalopathy, and renal dysfunction

Cellular Senescence: Inadequate glutathione accelerates cellular senescence (when cells stop dividing), contributing to aging tissues and organ dysfunction