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Analysis of the contribution of GSSG to the determined GSx contents for cells that had been treated without itaconate and its derivatives revealed that after a 6 h incubation, GSSG represented only around 3% of the determined cellular GSx and around 10% of the extracellular GSx (Table 1), demonstrating that GSH accounts for the large majority of intra and extracellular GSx contents and that the cells were not under any oxidative stress, consistent with literature data [34, 45]

14: Rates of enyzmatic reactions, 4th edn

Longer use does not increase benefits

The contraction and expansion of the pedicles, which can be regulated by actin microfilaments, can alter the size of the lacunae and the area of the glomerular filtration membrane, thereby regulating the glomerular filtration rate