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a narrative review and a prospective vision for planning clinical trials on this issue

These changes coupled with the increased ROS generation in aged RPE cells along with the reduction in the activities of antioxidative enzymes would constitute a situation conducive to the onset of AMD (222, 223)

These nanoparticles not only address the inefficiencies and side effects of traditional drug delivery methods but also enhance targeting and therapeutic effects through surface modifications 11,12

Moving beyond symptomatic management, targeting the core drivers of this pathological cycle holds promise for modifying disease progression