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Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

Idiopathic neuropathy When the cause of neuropathy is unknown, which affects roughly 25% of patients, a broad-spectrum approach targeting multiple mechanisms makes the most sense

et al (2020) SI Appendix for: Integrating smFRET, SAXS and NMR data to infer structural ensembles of an intrinsically-disordered protein