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Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination

Animal welfare was constantly monitored, and euthanasia was performed according to ethical regulations

[47] In addition, internalized "mega-complexes" consisting of a single GPCR, -arr(in the tail conformation), [48] [49] and heterotrimeric G protein exist and may account for protein signaling from endosomes

Lastly, the factors affecting varying alcohol sensitivity among GIRK isoforms remain unknown