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Tyrosinase activity can also increase the risk of developing hyperpigmentation of the cheeks, forehead, and upper lip, a condition known as melasma, which may remain after pregnancy

Normally, most of full-length PTH1-84 is transformed in the liver to the biologically active N-terminal PTH1-34 fragment and several other, inactive C-terminal fragments

Recent evidence also indicated that, as a transmembrane protein localized on the plasma membrane, SLC7A11 is also subjected to regulation by lysosomal degradation