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Velsor LW, van Heeckeren A, Day BJ: Antioxidant imbalance in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice

2.6 Knockdown of SjTGR or SjTRP14 blocked the survival of schistosomes and ameliorated egg-induced granulomatous pathology in mice To further evaluate the impacts of the SjTGR-mediated thiol-disulfide redox signaling pathway on the survival and oviposition of schistosomes, we performed a 38-day in vivo RNAi on SjTGR and its downstream substrate SjTRP14 starting from the 1st day of infection, individually (Fig 6A)