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The non-motor symptoms appear before the onset of motor symptoms for many years

40 Nanomaterials achieve local sterilization and targeted therapy in the stomach through a dual mechanism of carrier localization + active release: organic pH-sensitive liposomes and chitosan nanoparticles can control the release of antibiotics in the gastric acid microenvironment, protecting drugs and reducing off-target effects

J Am Soc Nephrol 31:12671281 Dong W, Jia Y, Liu X, Zhang H, Li T, Huang W, Chen X, Wang F, Sun W, Wu H (2017) Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

Typically, 3 to 6 sessions are required for visible improvement