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Persistent Evidence Gaps and the Antioxidant Paradox Although folic acid, iron, iodine, and multiple-micronutrient supplementation have robust evidence in low-resource settings, important uncertainties persist regarding optimal dosing of vitamin D, DHA, and choline in well-nourished populations, long-term epigenetic consequences of supra-physiological synthetic vitamin intake, and the true effectiveness of premium versus generic prenatal multivitamins in high-income countries [55,56,57]

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