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Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers

K.2011203240247 78

Where These Numbers Come From AOD-9604 has a notable research history including animal studies, human clinical trials, and FDA GRAS evaluation

This failure leads to neuronal swelling, disruption of dendritic architecture, and excessive neurotransmitter release, culminating in neurotransmitter-induced excitotoxicity (10, 29)