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Marked elevation of macrophage migration inhibitory factor in the peritoneal fluid of women with endometriosis

Environmental toxins and mitochondrial dysfunction Exposure to environmental toxins, such as heavy metals, pesticides, and endocrine-disrupting chemicals (EDCs), can significantly impair mitochondrial function

In STZ-induced DKD mice, it has been observed that PI3K/AKT activity is significantly elevated, whereas AMPK activity is markedly reduced, thereby promoting apoptosis (213, 214)