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Xia et al., 2025d) Looking ahead, research should focus on validating tissue-specific biomarkers and integrating spatial metabolomics with artificial intelligence technology to refine treatment strategies ( Statements Author contributions H-HX: Visualization, Writing original draft, Writing review & editing

Considering arginine has been recognized for its capacity to activate mTORC1 and persistent mTORC1 activation is a well-documented inducer event of cellular senescence, 22,23,24 we are interested to elucidate the relationship between glutaminolysis and mTORC1 activation, with particular attention to investigate if the senescence-associated reprogramming of glutaminolysis is connected with the senescence-associated persistent mTORC1 activation, i }\) norm(control) : The average value of the normalized consumption rate of the control

The Arterial EC3 subgroup, which is enriched in the mesenteric sample and therefore represents ECs from larger arteries, surprisingly shows higher levels of cell cycle genes compared to other arterial subpopulations (Fig