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[0248] The term "monoclonal antibody" as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations that may be present in minor amounts

Abstract Neurodegenerative diseases represent an expanding global health challenge, with rapidly increasing prevalence and substantial economic impact

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In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration