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Rotenone treated in vitro PD model showed impairment of lysosomal functions due to decreased NAD + /NADH and Sirt1 expression (Dong W et al., 2021)

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In addition, other enzymes also contribute to the cytosolic NADPH pool, such as IDHs, MEs, methylene-tetrahydrofolate dehydrogenases (MTHFDs), and 10-formyl-tetrahydrofolate dehydrogenases (FTHFDHs) (56, 111), all of which have both cytosolic and mitochondrial isozymes